Department of Chemical Engineering

張厚謙(Hou-Chien Chang)

Home Faculty & Staff Adjunct Chair Professor


職稱	副教授
電話	(04)2284-0510
E-mail	hchang@dragon.nchu.edu.tw
辦公室	408
個人網址
最高學歷	美國紐約州立大學水牛城分校化工系博士
研究領域	細胞間訊息傳遞、膠體粒子在孔隙薄膜中之分佈及運動、聚乙烯製程
簡要經歷
國立台灣大學化學工程學系學士 (1994) 美國紐約州立大學水牛城分校化工系博士 (2003) 美國德州台塑線性低密度聚乙烯廠製程工程師 (2001-2004) 國立中興大學化學工程學系助理教授 (2004-2011) 國立中興大學化學工程學系副教授 (2011-) B.S., Department of Chemical Engineering, National Taiwan University, 1994 Ph.D., Department of Chemical Engineering, The State University of New York at Buffalo, 2003 Process Engineer, LLDPE Plant, Formosa Plastics, Texas, 2001-2004 Assistant Professor, Department of Chemical Engineering, National Chung Hsing University, 2004- 2011 Associate Professor, Department of Chemical Engineering, National Chung Hsing University, 2011-

Teaching subject

Publications

A.期刊論文
	1.	Hou-Chien Chang*, Yen-Chang Lin and Che-Ting Kuo, “A Two-Dimensional Diffusion Model Quantifying Intracellular Transport with Independent Factors Accounting for Cytosol Viscosity, Binding, and Steric Hindrance,” Biochemical Engineering Journal, vol.217-227, no.41, 2008. (SCI)
	2.	Li-Hsun Chang, Chun-Ting Shen, Shur-Jong Hsieh, Shih-Lan Hsu, Hou-Chien Chang, Chieh-Ming J. Chang, “Recovery and Enhancement of Unsaturated Fatty Acids in Soft-Shelled Turtle Fish Oil using Supercritical Carbon Dioxide and Associated Catalase Release Activity,” Separation and Purification Technology, vol.64(2), no.213-220, 2008. (SCI)
	3.	Johannes M. Nitsche, Hou-Chien Chang, Paul A. Weber, and Bruce J. Nicholson,, “A Transient Diffusion Model Yields Unitary Gap Junctional Permeabilities from Images of Cell-to-Cell Fluorescent Dye Transfer Between Xenopus Oocytes,” Biophysical Journal, vol.86, pp.2058-2077, 2004.
	4.	Paul A. Weber, Hou-Chien Chang, Kris E. Spaeth, Johannes M. Nitsche and Bruce J. Nicholson, “ The Permeability of Gap Junction Channels to Probes of Different Size is Dependent on Connexin Composition and Permeant-Pore Affinities,” Biophysical Journal, vol.87, pp.958-973, 2004.
	5.	Hou-Chien Chang, “Equilibrium Partitioning and Transport Processes within Pores and Coupled Cellular Compartments: Micro- and Macroscopic Theory, and Biological Application,” 2003.
	6.	B. J. Nicholson, P. A. Weber, H. C. Chang, J. M. Nitsche , “Permeabilities of heterotypic and heteromeric gap junction channels reveal unique properties,” Molecular Biology of the Cell, vol.13, pp.1971, 2002.
	7.	Paul A. Weber, Hou-Chien Chang, Bruce J. Nicholson, and Johannes M. Nitsche, “Gap Junction Pore Size Exclusion Limits are Controlled by Connexin Composition,” Molecular Biology of the Cell, vol.11, pp.1707, 2000.
	8.	B. J. Nicholson, P. A. Weber, F. Cao, H. C. Chang, and G. , “GoldbergThe Molecular Basis of Selective Permeability of Connexins is Complex and Includes Both Size and Charge,” Brazilian Journal of Medical and Biological Research, vol.33, no.4, pp.369-378, 04 2000.
	9.	Paul A. Weber, Hou-Chien Chang, Bruce J. Nicholson, and Johannes M. Nitsche, “Gap Junction Pore Size Exclusion Limit is Controlled by Connexin Composition,” Molecular Biology of the Cell, vol.10, pp.2345, 1999.
	10.	Hou-Chien Chang*, Hong-Lin Chu, Yi-Fang Wang, Chun-Yuan Shih and Hui-Ming Wang, “A Quantitative Study on Transdermal Delivery Process of Salicylic Acid and Acetylsalicylic Acid (Aspirin) Using HPLC Method,” Submitted to Biochemical Engineering Journal, under review. (SCI)
	11.	2. Hui-Min Wang*, Chung-Yi Chen, Chun-Yen Chen, Mei-Ling Ho, Hou-Chien Chang, Yi-Ting Chou, Chih-Hung Lee, Chau-Zen Wang, and I-Ming Chu, “(-)-N-Formylanonaine from Michelia alba as human tyrosinase inhibitor and antioxidant,” Submitted to Journal of Nature Products, under review. (SCI)

B.研討會論文
	1.	褚鴻霖、施淳元、張厚謙, “以水楊酸與阿斯匹靈探討藥物分子性質與經皮吸收效率之關聯,” 2009化工年會, Taichung, Taiwan, 2009.
	2.	褚鴻霖、施淳元、張厚謙, “以水楊酸與阿斯匹靈探討藥物分子性質與經皮吸收效率之關聯,” 化工年會, Taichung, Taiwan, 2009.
	3.	吳信賢、張厚謙、王怡芳, “Quantificaion of Porcine Skin Diffusivity in Transdermal Diffusion with a Numerical Model,” 2008輸送現象研討會, Taipei, Taiwan, 2008.
	4.	林彥菖、張厚謙、郭哲庭, “A Mathematical Two-Dimensional Model Accounting for Binding Mechanisms in Intracellular Diffusion,” 2007輸送現象研討會, Taipei, Taiwan, 2007.
	5.	蔡輝彥、張厚謙、吳信, “The Calculation and Study on the Window Effects in Zeolite Diffusion with a Two-Dimensional Model,” 2007 化工年會, Taoyuan, Taiwan, 2007.
	6.	林彥菖,周季呈,蔡輝彥,鄭培琳,張厚謙, “A Mathematical Model Quantifying Cytoplasmic Transport of Biomolecules,” 2006輸送現象研討會, Taipei, Taiwan, 2006.
	7.	沈書弘、張厚謙, “The Calculation and Study on the Interaction between Spherical and Nonspherical Particles,” 2005化工年會, Miao-Li, Taiwan, 2005.
	8.	Hou-Chien Chang and Paul A. Weber, “A Mathematical Model of Dye Transfer Experiment Quantifies the Gap Junctional Permeability as a Function of Pore Type and Permeant Physicochemistry,” Presented at AIChE Annual Meeting 1999, Dallas, 1999.

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